Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Product code: 10-4172

Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human
Conjugate : Unconjugated

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Shipping Info:

2000 (throughout India)

Order now and get it on next 3-4 working days* (Major Cities)


Gene : VTCN1
Gene ID : 79679
Uniprot ID : Q7Z7D3
Alternative Name : V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1
Format : Purified
Amount : 100 µg
Clone name : ABM53A6
Isotype : Mouse IgG2a, k
Immunogen Information : A partial length recombinant protein (a.a 23-220) of B7-H4 was used as the immunogen for this antibody.

B7-H4, a member of B7 family, is a transmembrane protein that has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. B7-H4 mRNA is widely distributed in mouse and human peripheral tissues and can be induced in monocytes, macrophages, and dendritic cells upon IL-6 and IL-10 stimulation. However, in a variety of tumor cells, B7-H4 is predominantly present in intracellular compartments with unknown mechanism and functions. Cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. The overexpression of B7-H4 has been found in various types of human tumors, such as breast cancer, renal cell carcinoma (RCC), ovarian cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer and melanoma etc, where its expression level is positively correlated with disease progression. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

FACS: 0.5-1  µg/10^6 cells; Immunohistochemical analysis: 5 µg/mlWestern blot analysis: 2-4 µg/ml


Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Product code: 10-4172
mg

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