|
|
| Gene : |
NLRC4 |
| Gene ID : |
58484 |
| Uniprot ID : |
Q9NPP4 |
| Alternative Name : |
NLRC4, CARD12, CLAN, CLAN1, IPAF, UNQ6189/PRO20215 |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A synthetic peptide of IPAF/ClAN/CARD12 (amino acis 637-654 EEAPETYIPSRAVSLFFN) was used as immunogen for this antibody |
Ipaf (also known as Clan/CARD12) is a CARD domain containing protein. In general CARD proteins are implicated in host defense against infection, environmental stress or cellular damage. CARD domains are found in the N-terminal pro-domains of certain caspases, a family of apoptotic and pro-inflammatory proteases, as well as in a diversity of other proteins including Ipaf/Clan/CARD12. There are at least three major signaling pathways in which CARD proteins act: (1) Regulation of caspase activation in the context of apoptosis (2) Regulation of caspase activation in the context of inflammation (3) Regaultion of NF-kB activation in the context of innate or adaptive immune responses. As there is significant crosstalk between pathways that lead to caspase-mediated apoptosis or inflammation and pathways that result in NF-kB activation, it is logical that similar protein modules such as CARD domains are found repeatedly in proteins from all three pathways. Ipaf plays a role in regulating caspase-1 activity, which in turn mediates the maturation of inflammatory cytokines IL-1b and IL-18. Ipaf also interact with the pro-apoptotic adaptor protein ASC and co-expression of Ipaf with ASC has been shown to induce NF-kB activation and apoptosis.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
